Mutagenic and antimutagenic evaluation of total extracts of medicinal plants by the retromutation test in Salmonella typhimurium
Keywords:
Extractos metanólicos, Plantas medicinales, Test de Ames.Abstract
In various regions of the South of the Ecuador different plant species are used to treat a variety of ailments. Methanol extracts from plants used in traditional medicine in the province of Loja, were investigated with the objective of evaluating their possible potential mutagenic and antimutagenic using retromutation test in Salmonella typhimurium(Ames Test) with bacterial strains TA1535, TA1538, TA98 and TA100 (mutagenicity test), TA100 and TA98 (antimutagenicity test) in the absence of metabolic activation (-S9). Methanol extracts from the leaves of Baccharis latifolia and Callisia repens were positive for mutagenicity testing. Ludwigia peruviana was found to be strongly antimutagenic againts at least one of the mutagens tested. These results contribute to valuable data on the safe use of medicinal plants and their potential chemopreventive effects. Considering the excellent antimutagenic activities extracted from Ludwigia peruviana these extracts are good candidate source of chemopreventive agent. However, Baccharis latifolia and Callisia repens showed mutagenic activity, suggesting caution in their use. The mutagenic and antimutagenic activity of these species indicates that they are valuable resources that should be conserved and considered for future research.Metrics
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